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DMT

Also known as: n,n-dmt, dimethyltryptamine

Chemical structure of DMT

A popular and powerful psychedelic, typically used in two ways; either it is vapourised for a short 'breakthrough' experience, or it is taken in combination with an enzyme inhibitor for a long, intense trip (this is also known as ayahuasca or pharmahuasca).

Dosage

Insufflated

Common: 25-50mg
Light: 10-25mg
Strong: 50-125mg+

Intravenous

Common: 15-25mg
Light: 10-15mg
Strong: 25-40mg

Vapourized

Common: 15-25mg
Heavy: 35mg+
Light: 10-15mg
Strong: 25-35mg
Threshold: 5-10mg

NOTE: These figures are for 100% effective vaporization methods. Most methods are not 100% effective. Likelyhood of having a "breakthrough" experience increases with dose.

Duration

Onset: undefined minutes
Duration: undefined minutes
After effects: 15-60 minutes

Timeline

After
15-60 minutes
030m1h
Typical
Extended range

Effects

immersive experienceopen eye visualsradical perspective shiftingprofound life-changing spiritual experiencespowerful rushing of sensationchange in perception of timeauditory hallucinationscolor shiftinghard on lungs when smokingstomach discomfortdifficulty integrating experiencesoverwhelming fear

Half-life

10-20 minutes

Drug Interactions

lithium

There is a large number of reports indicating a high seizure and psychosis risk from this combination.

Dangerous
tramadol

Tramadol is well known to lower seizure threshold and psychedelics also cause occasional seizures.

Unsafe
amphetamines

Stimulants increase anxiety levels and the risk of thought loops which can lead to negative experiences

Caution
cannabis

Cannabis has an unexpectedly strong and somewhat unpredictable synergy with psychedelics.

Caution
cocaine

Stimulants increase anxiety levels and the risk of thought loops which can lead to negative experiences

Caution
2c t x
Low Risk & Synergy
2c x
Low Risk & Synergy
5 meo xxt
Low Risk & Synergy
alcohol
Low Risk & Decrease
amt
Low Risk & Synergy
benzodiazepines
Low Risk & Decrease
caffeine
Low Risk & No Synergy
dextromethorphan
Low Risk & Synergy
dox
Low Risk & Synergy
ghb/gbl
Low Risk & Decrease
ketamine
Low Risk & Synergy
lsd
Low Risk & Synergy
maois
Low Risk & Synergy
mdma
Low Risk & Synergy
mescaline
Low Risk & Synergy
mushrooms
Low Risk & Synergy
mxe
Low Risk & Synergy
nbomes
Low Risk & Synergy
nitrous
Low Risk & Synergy
opioids
Low Risk & No Synergy
pcp
Low Risk & Synergy
ssris
Low Risk & Decrease

Structure © Wikimedia