A popular dissociative drug which is an analogue of ketamine, though less sedating and more potent by weight, with a subjectively more 'complicated' set of effects.
Dosage
Insufflated
Oral
Sublingual
NOTE: Bodyweight plays a slight factor in MXE dosing, these are values for a 175lb (80kg) male
Duration
Timeline
Avoid
Alcohol, Benzodiazepines, Opioids, Other CNS depressants, including substances that have an effect on Serotonin (For example, yet not limited to MDMA, Amphetamine, and other stimulants)
Drug Interactions
There is a high risk of memory loss, vomiting and severe ataxia from this combination.
Both substances cause ataxia and bring a risk of vomiting and unconsciousness. If the individual falls unconscious while under the influence there is a severe risk of vomit aspiration if they are not placed in the recovery position.
This combination can potentiate the effects of the opioid
There is a risk of serotonin syndrome when combining DXM with MXE, due to DXM and MXE both being SRI’s. MXE and DXM having notable affinities for the serotonin transporter.
MAO-B inhibitors appear to increase the potency of MXE. MAO-A inhbitors have some negative reports associated with the combination but there isn't much information available
Risk of tachycardia, hypertension, and manic states
Both substances potentiate the ataxia and sedation caused by the other and can lead to unexpected loss of consciousness at high doses. Place the affected individual in the recovery position to prevent vomit aspiration from excess.
Stimulants taken with MXE can lead to hypermanic states much more easily, especially if sleep is avoided.
As an NMDA antagonist MXE potentiates DOx which can be unpleasantly intense
There have been reports of risky serotonergic interactions when the two are taken at the same time, but MXE taken to the end of an MDMA experience does not appear to cause the same issues.
As an NMDA antagonist MXE potentiates NBOMes which can be unpleasantly intense
There are no reports available about this combination
Depending on the SSRI this combination can be unpredictable
Little information exists about this combination.
No likely interactions