Lithium

There is a large number of reports indicating a high seizure and psychosis risk from this combination.

There is a large number of reports indicating a high seizure and psychosis risk from this combination.

There is a large number of reports indicating a high seizure and psychosis risk from this combination.

There is a large number of reports indicating a high seizure and psychosis risk from this combination.

There is a large number of reports indicating a high seizure and psychosis risk from this combination.

High risk of serotonin syndrome

There is a large number of reports indicating a high seizure and psychosis risk from this combination.

There is a large number of reports indicating a high seizure and psychosis risk from this combination.

There is a large number of reports indicating a high seizure and psychosis risk from this combination.

Tramadol and Lithium both increase the risk of seizures and serotonin syndrome.

Lithium may inhibit some of the recreational effects of cocaine.

We are unable to find a report of concerns for CNS depression caused by Lithium.

This interaction is used in medical settings without reported issues. If this combination is taken, caution would be recommended if any other drugs are planned to be taken on top of these that may have serotonergic activity.