← Back to all substances
Clomethiazole
Structurally related to Thiamine (vitamin B1), but with binding potential at the GABAa site, which causes it to produce effects most like those of a barbiturate: an effective sedative and hypnotic. Originally developed by Hoffman-LaRoche in the 1930s, it has seen use as a treatment for acute alcohol withdrawal.
Dosage
Oral
Common: 150-200mg
Heavy: 200mg+
Light: 100-150mg
Threshold: 100mg
Duration
Onset: 15-40 minutes
Duration: 5-8 hours
After effects: 1-16 hours
Timeline
Onset
15-40 minutes
Peak
5-8 hours
After
1-16 hours
012.3h1.0d
Typical
Extended range
Effects
AnxiolyticSedativeMuscle RelaxantAmnesiaDystaxiaHypnotic