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Caffeine

Also known as: coffee

Caffeine is a a CNS stimulant, and also the most widely used psychoactive substance in the world. It is legal and unregulated in most parts of the world, and is found in many commonly sold products. It has a good safety profile, though regular heavy use can cause physical dependence and contribute to certain medical conditions.

Dosage

Oral

Common: 75mg-250mg
Heavy: 400mg+
Light: 20-75mg
Strong: 250-400mg
Threshold: 10-20mg

NOTE: The lethal dose for caffeine starts at approximately 3g. The average cup of coffee contains roughly 75-150mg of caffeine.

Duration

Onset: 5-10 minutes
Duration: 1.5-5 hours
After effects: 3-4 hours

Timeline

Onset
5-10 minutes
Peak
1.5-5 hours
After
3-4 hours
04.6h9.2h
Typical
Extended range

Effects

elevated heartrateincrease in cognitive abilitiesphysical agitationpanicked thinkingracing thoughtsuncomfortable bodyload

Drug Interactions

amphetamines

This combination of stimulants is not generally necessary and may increase strain on the heart, as well as potentially causing anxiety and greater physical discomfort.

Caution
amt

High doses of caffeine may cause anxiety which is less manageable when tripping, and since both are stimulating the combination may cause some physical discomfort.

Caution
cocaine

Both stimulants, risk of tachycardia, hypertension, and in extreme cases heart failure.

Caution
dextromethorphan

High doses of caffeine can potentially exacerbate anxiety, especially during a dissociative experience, due to its stimulating effects. This combination might also lead to physical discomfort. However, individual responses to caffeine can vary significantly, often influenced by factors like habitual versus occasional usage.

Caution
dox

High doses of caffeine may cause anxiety which is less manageable when tripping, and since both are stimulating it may cause some physical discomfort.

Caution
mdma

Caffiene is not really necessary with MDMA and increases any neurotoxic effects from MDMA

Caution
nbomes

Caffiene can bring out the natural stimulation from psychedelic drugs to make it uncomfortable. High doses can cause anxiety which is hard to handle while tripping

Caution
pcp

Details of this combination are not well understood but PCP generally interacts in an unpredictable manner.

Caution
2c t x

High doses of caffeine may cause anxiety which is less manageable when tripping, and since both are stimulating the combination may cause some physical discomfort.

Low Risk & No Synergy
2c x

High doses of caffeine may cause anxiety which is less manageable when tripping, and since both are stimulating the combination may cause some physical discomfort.

Low Risk & No Synergy
5 meo xxt

High doses of caffeine may cause anxiety which is less manageable when tripping, and since both are stimulating the combination may cause some physical discomfort.

Low Risk & No Synergy
alcohol
Low Risk & No Synergy
benzodiazepines
Low Risk & Decrease
cannabis
Low Risk & No Synergy
dmt
Low Risk & No Synergy
ghb/gbl
Low Risk & No Synergy
ketamine

No unexpected interactions.

Low Risk & No Synergy
lsd
Low Risk & No Synergy
maois
Low Risk & No Synergy
mescaline

High doses of caffeine are uncomfortable and this will be magnified by psychedelics

Low Risk & No Synergy
mushrooms
Low Risk & No Synergy
mxe

No likely interactions

Low Risk & No Synergy
nitrous
Low Risk & No Synergy
opioids
Low Risk & No Synergy
ssris
Low Risk & No Synergy
tramadol
Low Risk & No Synergy

Chemical structure © Wikimedia Commons